medication adherence in chronic disease

This information will help inform how best to formulate text message–based interventions for different patient cohorts. One study21 that used twice-daily text message reminders had a small fraction (6%) of participants reporting messages as being intrusive and inconvenient. However, about 50% of patients with chronic diseases do not take medication as prescribed. Background: Poor adherence to prescribed medication is a well-known problem. Medication adherence among patients with chronic diseases: a survey-based study in pharmacies.  et al. Also, do text message–based interventions work better in some groups of patients compared with others? World Health Organization. Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. In these interventions, people who have at least 1 chronic medical condition get text messages reminding or encouraging them to take their medicines as prescribed. Evidence-based medicine. Key words: Chronic kidney disease, treatment adherence, medication knowledge. 2. PMC The electronic database was last searched on January 15, 2015. 2018;8(1):e016982. This literature review was requested as background for a conference focusing on policy options to improve medication adherence. Mobile telephone text messaging may be a more feasible platform to deliver electronic reminders in practice.  C, Thirumurthy Dosing frequency and medication adherence in chronic disease. Improving medication adherence is a challenge. Medication adherence is a core component of chronic care management. apps on medication adherence in adults patients with chronic disease, (b) describe and examine the effect of characteristics of app interventions, and (c) describe participant’s perceptions At a generally acceptable threshold of 0.1 for the effect size, this value was 34, which means that we would need to locate an additional 34 studies with a mean standard difference in means of 0 to bring the combined standard difference in means to below 0.1.  O. If more than 1 publication of an original trial was identified, such articles were assessed together to maximize data collection. The short duration of the trials suggests uncertainty about the duration of the effect, the time-effect relationship, and the continuation or decay of the effect after the intervention is withdrawn. and R.K.) independently screened all identified titles and abstracts from the literature search using a predefined protocol.  R, Wilczynski  PR, Whitehead Long-term care. Lancet Reg Health Eur. Interventions that delivered personalized messages showed a moderate effect size (Cohen d, 0.63; 95% CI, 0.29-0.96; P < .01), which suggests that sending a text message with one’s preferred name may increase acceptance and participant engagement. Patient noncompliance with medical regimens is a major factor in therapeutic failure and is particularly detrimental to clinical trials.  S, Tweedie To determine the effect of scheduled dosing frequency on medication adherence in patients with chronic diseases. Global Observatory for eHealth Series Vol 3. Adherence to treatment, a public health issue, is of particular importance in chronic disease therapies. Author Contributions: Dr Thakkar had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Chronic Obstructive Pulmonary Disease (COPD) is one of the prominent cause of mortality worldwide. A population is considered adherent if 80% of people have access to their medications for at least 80% of days in a defined study period (e.g., 80% of 365 days). Clipboard, Search History, and several other advanced features are temporarily unavailable. 3. Effectiveness of an intervention to provide information to patients with hypertension as short text messages and reminders sent to their mobile phone (HTA-Alert) [in Spanish].  RB. The webcast featured a panel of leaders in pharmacy, nursing, medicine, and academia who highlighted the burden of medication nonadherence and barriers for adherence among patients with cardiovascular disease and other chronic diseases.  et al. No systematic review has examined the effectiveness of interventions designed to improve medication adherence.  WH, Lee Consequently, the reported incidence of poor medication adherence in patients with T2D ranged widely from 38% to 93% owing to widely different methodological … The use of more stringent definitions of adherence magnified these findings. Adherence to treatment is a process that begins with alertness about the disease and has to end with staying in treatment.  R, Wald We did not follow the alternative strategy of selecting a single pair of interventions because that can result in loss of information and introduce bias if the arm with positive results is preferentially included for analysis. Much of the evidence regarding poor medication adherence in diabetes is based on retrospective or observational studies that collect data from claim databases using a broad range of definitions. and R.K.) independently assessed the risk of bias of included studies, with any disagreements resolved by discussion and a third opinion (C.K.C.) Unity in Diversity and the Standardisation of Clinical Pharmacy Services represents the proceedings of the 17th Asian Conference on Clinical Pharmacy (ACCP 2017), held 28—30 July 2017 in Yogyakarta, Indonesia. The 8-item Morisky Medication Adherence Scale translated in German and validated against objective and subjective polypharmacy adherence measures in cardiovascular patients.  et al. This article provides an up-to-date review of the literature on medication …  P, Chinna Global Adherence Interdisciplinary Network. Another study found that medication adherence rate was 14 percent greater and discontinuation rate was 14 percent lower for program-supported patients, leading to 23 percent lower 12-month medical costs. doi: 10.1002/14651858.CD012042.pub2. This study examined medication adherence by characteristics of patients with chronic diseases. Most reported moderate to high levels of satisfaction with the program. The Morisky Medication Adherence Scale is a validated assessment tool used to measure non-adherence in a variety of patient populations. J Manag Care Pharm. The adherence cutoff was defined at 95% in 6 HIV trials and 1 CVD trial, at 90% in 1 HIV trial, at 80% in 1 CVD trial, and at 80% in one hypertension trial. Effect of lifestyle-focused text messaging on risk factor modification in patients with coronary heart disease: a randomized clinical trial.  P, Kahana, S., Drotar, D., & Frazier, T. (2008).  WS. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. Chronic diseases constitute a significant threat to health. Accessibility Park All patients took medication for chronic diseases such as heart disease, HIV, asthma and diabetes. Background. All rights reserved. While our analyses indicate some heterogeneity across clinical trials, this finding is likely because of variation in the characteristics of the interventions studied and in the definitions of outcomes among the studies. Objectives  For example, is there greater benefit with more text message sophistication such as fixed-frequency or real-time medication monitoring, matched short message service with medication times, varied message content, personalization, and 2-way communication? Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Odds ratios and pooled data were calculated using random-effects models. Manual searches of reference sections of identified studies and systematic reviews were also performed to find other potentially relevant articles. Objective: To study the prevalence and predictors of medication non-adherence in patients of CKD and outcomes of non-adherence prospectively over 2 years.  TP, Rimpelä Measuring, analyzing, and managing drug adherence in resistant hypertension.  L, Ongolo-Zogo Health Information Technology: Comprehensive Telehealth Interventions to Improve Diet Among Patients with Chronic Diseases external icon: Patients with cardiovascular disease, diabetes, end-stage renal disease, or obesity. Text message interventions were similarly effective when analyses were restricted to text message studies31,32,34,35,37,40-42 reporting outcomes by intent to treat (OR, 2.25; 95% CI, 1.51-3.37; P < .001; Cohen d, 0.45) (eFigure 1 in the Supplement) or by per-protocol analysis (OR, 1.65; 95% CI, 1.07-2.53; P = .02; Cohen d, 0.28) (eFigure 2 in the Supplement). The median intervention duration was 12 weeks, and self-report was the most commonly used method to assess medication adherence. US Food and Drug Administration. Manual searches of reference sections of included studies as well as systematic reviews were performed to identify other potentially relevant articles.  Z, Participant feedback on text message acceptability was reported in 11 studies (Table 2). Background: More than 25% of primary care patients are managing multiple chronic conditions (MCC) and 50% of their medications are not taken as prescribed. to reach consensus. B.D. Drug therapy – utilization.  C, Xi a. The patients in our meta-analysis were middle-aged (age range, 31-64 years), and 50.3% (1380 of 2742) were female. Health care providers can personalize the messages for patients, … This increase translates into adherence rates improving from 50% (assuming this baseline rate in patients with chronic disease) to 67.8%, or an absolute increase of 17.8%. Here are just a few examples of the raving reviews for Evidence-Based Medicine Guidelines: "An excellent resource… quick to use, even during consultations…very helpful to check whether our preferred diagnostic and therapeutic methods ... Materials and methods. However, in patients with multiple chronic diseases, those who had higher positive attitudes and feeling of necessity had higher odds [1.4 (1.1 - 1.9)] of having adherence Patients with chronic diseases appear to be more adherent with once-daily compared with more frequently scheduled medication regimens.  J, Chung Examining adherence in patients with CVD is a useful model for helping physicians understand medication adherence in other chronic conditions. The adherence measures examine individuals’ prescription claims for specific classes of medication therapy.

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